Isobel Crosswhite continued her impressive start to the new season with a team-high 17 points in the loss, while teammate Teal Mostovoy added 15.
With the loss, the Fortuna girts are now 1-1.
A busy week for the Huskies continues on Thursday when they open play at the Arcata tournament.
Fortuna plays Mazama at 8:30 p.m.
The Fortuna JVs and freshmen teams were also in action on Tuesday.
The JVs posted a comfortable 48-21 win over Ukiah, while the freshmen dropped a close one to Eureka, with the Loggers winning 38-36.