The victory was the second in three nights for the Huskies, who improved to 2-0.
Gracie Betts scored a team-high 14 points in the win, while Gabby Stephens added 11 points and Saige Grundman 10.
Both teams started slow, with just seven combined points in the opening quarter, before the Huskies took control of the game with a big second quarter to lead by nine at halftime,
The Crusaders responded after the interval, however, pulling back within five heading into the final period.
Lele Tanuvasa scored a team-high 14 points for St. Bernard’s, while teammate Madelyn Shanahan finished with 12 points in her high school debut.
The game was the first for the Crusaders, who play against Eureka on Saturday.
The Huskies have a bye this weekend before hosting McKinleyville on Monday.